Newly-accepted Manuscripts and Preprints

Si H, Esquivel M, Mendoza Mendoza E, Roarty K. The Covert Symphony: Cellular and Molecular Accomplices in Breast Cancer Metastasis. Frontiers in Cell and Developmental Biology. 2023 Jun 27;11:1221784. doi: 10.3389/fcell.2023.1221784. eCollection 2023. PMID: 37440925 

Kevin Roarty1,2,*. Taking shape: Intercalation within the mammary terminal end bud. Developmental Cell 58, July 10, 2023. doi:

Kevin Roarty 1,2,*. Unlocking the secrets of cancer stem cells: Immune checkpoint inhibitors face their formidable foes. Cell Stem Cell 30, June 1, 2023. doi: PMID: 37267909

Our manuscript was recently published in the 6th Special Issue of FORCES ON AND WITHIN CELLS for Molecular Biology of the Cell! Hongjiang Si1, Na Zhao1, Andrea Pedroza1, Ana-Maria Zaske2, Jeffrey M Rosen1,3, Chad J Creighton3,4, Kevin Roarty1,3,* Noncanonical Wnt/Ror2 signaling regulates cell-matrix adhesion to prompt directional tumor cell invasion in breast cancer. Molecular Biology of the Cell. 2022 Sep 15:33(11):ar103. doi: 10.109/mbc.E22-02-0055 Epub 2022 Aug 24. PMID: 36001375


Zhao N, Powell RT, Yuan X, Bae G, Roarty K, Stossi F, Strempfl M, Toneff MJ, Johnson HL, Mani SA, Jones P, Stephan CC, Rosen JM. Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition. Nature Communications. 2021 Jul 12;12(1):4262. PMID: 34253738; PMCID: PMC8275587.

Kevin Roarty and Gloria Echeverria. Laboratory Models for Investigating Breast Cancer Therapy Resistance and Metastasis. Front. Oncol., 10 March 2021 |

Nguyen TM, Kabotyanski EB, Dou Y, Reineke LC, Zhang P, Zhang XH, Malovannaya A, Jung SY, Mo Q, Roarty K, Chen Y, Zhang B, Neilson JR, Lloyd RE, Perou CM, Ellis MJ, Rosen JM. FGFR1-Activated Tranlation of WNT Pathway Components with Structured 5’ UTRs Is Vulnerable to Inhibition of EIF4A-Dependent Translation Initiation. Cancer Res. 2018 Aug 1;78(15):4229-4240.

Sreekumar A, Toneff MJ, Roarty K, Creighton CJ, Belka GK, Lee DK, Xu J, Chodosh LA, Richards JS, and Rosen JM. WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis.  Dev Cell. 2017 Oct 31. pii: S1534-5807(17)30820-1.

Roarty K, Pfefferle AD, Creighton CJ, Perou CM, and Rosen JM.  Ror2-mediated alternative Wnt signaling regulates cell fate and adhesion dynamics during mammary tumor progression. Oncogene. 2017 Oct 26;36(43):5958-5968. 2017 doi: 10.1038/onc2017.206

Sreekumar A, Roarty K, Rosen JM. The mammary stem cell hierarchy: A looking glass into heterogeneous breast cancer landscapes. Endocr Relat Cancer. 2015 Dec;22(6):T161-76.

Roarty K, Shore AN, Creighton CJ, Rosen JM. Ror2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium. J Cell Biol. 2015 Feb 2;208(3):351-66. ** JCB In Focus Feature: A Ror Recruit to Mammary Gland Development; 208 (3): 253.

Wei W, Tweardy DJ, Zhang M, Zhang X, Landua J, Petrovic I, Bu W, Roarty K, Hilsenbeck SG, Rosen JM, Lewis MT. STAT3 signaling is activated preferentially in tumor-initiating cells in claudin-low models of human breast cancer. Stem Cells. 2014 Oct;32(10):2571-82.

Roarty K, Rosen JM. Paracrine signaling in mammary gland development: what can we learn about intratumoral heterogeneity? Breast Cancer Res. 2014 Jan 29;16(1):202. (REVIEW)

Roarty K, Rosen JM. Pygopus 2: tilting the Wnt-Notch balance in mammary epithelial lineage determination. Breast Cancer Res. 2013.Dec 23; 15(6):322. (REVIEW)

Pond AC, Bin X, Batts T, Roarty K, Hilsenbeck S, Rosen JM. Fibroblast growth factor receptor signaling is essential for normal mammary gland development and stem cell function.  Stem Cells 2013. (1):178-89.

Shore AN, Kabotyanski EB, Roarty K, Smith MA, Zhang Y, Creighton CJ, Dinger ME, Rosen JM. Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation.    PLoS Genetics 2012;8(7):e1002840. 

Meerbrey KL, Hu G, Kessler JD, Roarty K, Li MZ, Fang JE, Herschkowitz JI, Burrows AE, Ciccia A, Sun T, Schmitt EM, Bernardi RJ, Fu X, Bland CS, Cooper TA, Schiff R, Rosen JM, Westbrook TF, Elledge SJ.  The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Proc Natl Acad Sci. 2011 Mar 1;108(9):3665-70.

Roarty K, Rosen JM.  Wnt and mammary stem cells: hormones cannot fly wingless. Curr Opin Pharmacol. 2010 Dec;10(6):643-9. (REVIEW)

Qin H, Wang L, Feng T, Elson CO, Niyongere SA, Lee SJ, Reynolds SL, Weaver CT, Roarty K, Serra R, Benveniste EN, Cong Y.  TGF-b promotes TH17 cell development through inhibition of SOCS3. J Immunol. 2009 Jul 1;183(1):97-105.

Roarty K, Baxley SE, Crowley MR, Frost AR, Serra R. Loss of TGF-beta or Wnt5a results in an increase in Wnt/beta-catenin activity and redirects mammary tumour phenotype. Breast Cancer Res. 2009;11(2):R19.   

Johnson E, Nicola T, Roarty K, Yoder BK, Haycraft CJ, and Serra, R. A role for cilia in the regulation of mouse ovarian function. Developmental Dynamics 2008. 237(8):2053-2060.

Brantley EC, Nabors LB, Gillespie GY, Choi YH, Palmer CA, Harrison K, Roarty K, Benveniste EN.  Loss of PIAS3 Expression in Glioblastoma Multiforme Tumors: Implications for STAT-3 Activation and Gene Expression. Clinical Cancer Research 2008. 1;14(15):4694-704

Roarty K, and Serra R. Wnt5a is required for proper mammary gland development and TGF-b-mediated inhibition of ductal growth.  Development. 2007.  134(21):3929-39. **Faculty of 1000